Fluconazole for the treatment of onychomycosis: an update.

نویسندگان

  • A K Gupta
  • R K Scher
  • P Rich
چکیده

Onychomycosis is a common nail disorder thought to occur in approximately 7-9% of the North American population.v" Until quite recently, there was a paucity of effective and safe therapies for onychomycosis, particularly pedal disease. Griseofulvin was the first significant oral antifungal agent to become available for the treatment of onychomycosis.v? Since then, other oral antifungal agents have been reported for use in this disorder: . ketoconazole, itraconazole, terbinafine, and fluconazole. In this article, the literature pertaining to fluconazole therapy for the management of onychomycosis is reviewed. The advantages of fluconazole include its high efficacy rate, low relapse rate, broad action spectrum, weekly treatment regimen that results in high compliance, and a favorable adverse effects profile. Fluconazole was first approved in France and the UK in 1988 for systemic mycoses. It is estimated that fluconazole has now been used more than 50 million times worldwide (Pfizer, USA, personal communication, May 1997).

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عنوان ژورنال:
  • International journal of dermatology

دوره 37 11  شماره 

صفحات  -

تاریخ انتشار 1998